In the remote sands of the Moroccan desert, a rifle shot rings out - detonating a chain of events that will link an American tourist couple's frantic struggle to survive, two Moroccan boys involved in an accidental crime, a nanny illegally crossing into Mexico with two American children, and a Japanese teen rebel whose father is sought by the police in Tokyo.

Separated by clashing cultures and sprawling distances, each of these four disparate groups of people are nevertheless hurtling towards a shared destiny of isolation and grief. In the course of just a few days, they will each face the dizzying sensation of becoming profoundly lost - lost in the desert, lost to the world, lost to themselves - as they are pushed to the farthest edges of confusion and fear as well as to the very depths of connection and love.